Piperidine-substituted benzoic acid compound, and pharmaceutical composition and use thereof

A compound of formula (I), a stereoisomer thereof, a tautomer thereof, an isotopically labeled compound thereof, or a pharmaceutically acceptable salt of any one of the foregoing:

• wherein
• p is 0, 1, or 2;
• L is a single bond, NRe, O, or S;
• R1 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 cycloalkynyl, —C1-3 alkyl-C3-6 cycloalkyl, “3- to 12-membered heterocycloalkyl with 1, 2, or 3 heteroatoms selected from 1, 2, or 3 types of N, O, and S″, —C1-3 alkyl-“3- to 12-membered heterocycloalkyl with 1, 2, or 3 heteroatoms selected from 1, 2, or 3 types of N, O, and S″, or the following group substituted by one or more Ra:
• C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 cycloalkynyl, —C1-3 alkyl-C3-6 cycloalkyl, “3- to 12-membered heterocycloalkyl with 1, 2, or 3 heteroatoms selected from 1, 2, or 3 types of N, O, and S″, or —C1-3 alkyl-“3- to 12-membered heterocycloalkyl with 1, 2, or 3 heteroatoms selected from 1, 2, or 3 types of N, O, and S″;
• m and n are each independently 0, 1, 2, 3, or 4;
• R2, R3, R4, R5, R7, R8, and R9 are each independently hydrogen, halogen, OH, CN, NO2, NH2, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 cycloalkynyl, —C1-3 alkyl-C3-6 cycloalkyl, or the following group substituted by one or more Rb:
• C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 cycloalkynyl, or —C1-3 alkyl-C3-6 cycloalkyl;
• R0 and R6 are each independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 cycloalkynyl, —C1-3 alkyl-C3-6 cycloalkyl, or the following group substituted by one or more Rc:
• C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C3-6 cycloalkynyl, or —C1-3 alkyl-C3-6 cycloalkyl;
• X is —C(═O)—, —C(═NR10)—, —C(═S)—, —CFR11—, —NR12—, —CR13R14—CR15R16—, —S—, or —S(═O)2—;
• R11, R13, R14, R15, and R16 are each independently hydrogen, halogen, OH, CN, NO2, NH2, C1-6 alkyl, C3-6 cycloalkyl, or the following group substituted by one or more Rd:
• C1-6 alkyl or C3-6 cycloalkyl;
• R10 and R12 are each independently hydrogen, C1-6 alkyl, or C1-6 alkyl substituted by one or more Re;
• Ra, Rb, Re, Rd, and Re are each independently halogen, OH, CN, NO2, or NH2.