Phenol derivative

A compound represented by formula (2) or pharmaceutically acceptable salt thereof:

• wherein
• R1 is a hydrogen atom, a C1-6 alkyl group, an optionally substituted C1-6 alkylcarbonyl group, or an optionally substituted C6-10 arylcarbonyl group, the C1-6 alkyl group being optionally substituted with one to three substituents, that are the same or different, selected from a hydroxyl group, a carboxyl group, and —NR11R12,
• R2 is a methoxy group, a hydroxyl group, or a hydrogen atom,
• R3 is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C1-4 alkoxy group, an optionally substituted C6-10 aryl group, or a formyl group,
• R4 is an optionally substituted C1-6 alkyl group, an optionally substituted C3-7 alicyclic group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group, an optionally substituted C6-10 aryl group, an optionally substituted C1-6 alkoxy group, an optionally substituted C3-7 alicyclic oxy group, an optionally substituted C6-10 aryloxy group, or an optionally substituted 4- to 7-membered non-aryl heterocyclic group,
• when R4 is an optionally substituted 4- to 7-membered non-aryl heterocyclic group, a carbon atom on the non-aryl heterocycle is bonded to the carbonyl group,
• R11 is a hydrogen atom, an optionally substituted C1-3 alkyl group, a formyl group, an optionally substituted C1-3 alkylcarbonyl group, an optionally substituted C1-4 alkoxycarbonyl group, or an optionally substituted C6-10 arylcarbonyl group,
• R12 is a hydrogen atom or an optionally substituted C1-3 alkyl group,
• m is 0, 1, or 2,
• n is 0, 1, 2, or 3,
• L1 is —NH—C(═O)—, —C(═O)—NH—, —NH—C(═S)—, —C(═S)—NH—, —NH—C(═O)—CH2—, —C(═O)—NH—CH2—, —NH—C(═O)—CH2—CH2—, —C(═O)—NH—CH2—CH2—, —SO2—NH—, —NH—SO2—, —NH—C(═O)—O—, or —O—C(═O)—NH—,
• L2 is a single bond or an optionally substituted C1-6 alkyl group,
• X is an optionally substituted phenyl group or an optionally substituted 6-membered heteroaryl group;
• Y is an optionally substituted phenyl group, an optionally substituted 5-membered or 6-membered heteroaryl group, an optionally substituted C3-7 alicyclic group, or an optionally substituted 4- to 7-membered non-aryl heterocyclic group, and
• X and Y are bonded at a carbon atom on each ring,
• provided that compounds as follows are excluded:
• (1) a compound of formula (W-1):
• R1a being a hydrogen atom or an acetyl group, and L1a being —C(═O)—NH— or —SO2—NH—;
• (2) a compound of formula (W-2):
• R1b being a methyl group or —CD3, R2b being formula (W-2A), (W-2B), (W-2C), (W-2D), or (W-2R):
• * being a bonding position with O, R3b being formula (W-2E), (W-2F), (W-2G), (W-2H), (W-2I), (W-2J), (W-2K), (W-2L), (W-2M), (W-2N), (W-2O), (W-2P), or (W-2Q):
• * being a bonding position with C═O, Xb being CH or N, Yb being CH or N, and Zb being —CH2— or —CHD-;
• (3) 4′-{[2-(3,4-dimethoxyphenyl)ethyl]carbamoyl}[1,1′-biphenyl]-4-yl acetate;
• (4) 2′-(2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-oxoethyl)-4,4′,5,5′-tetramethoxy[1,1′-biphenyl]-2-yl acetate;
• (5) (2′-{[2-(3,4-dimethoxyphenyl)ethyl]carbamoyl}-4,4′,5,5′-tetramethoxy[1,1′-biphenyl]-2-yl)methyl benzoate;
• (6) 6-[4-methoxy-2-(2-{4-[2-(piperidin-1-yl)ethoxy]phenyl}acetamido)phenyl]-5,6,7,8-tetrahydronaphthalen-2-yl 2,2-dimethylpropanoate;
• (7) 4′-{[(4-methoxyphenyl)methyl]sulfamoyl}[1,1′-biphenyl]-4-yl acetate;
• (8) 4′-{[(4-methoxyphenyl)methyl]sulfamoyl}[1,1′-biphenyl]-4-yl benzoate;
• (9) 4′-{[(4-methoxyphenyl)methyl]sulfamoyl}[1,1′-biphenyl]-4-yl 4-chlorobenzoate;
• (10) 4′-{[(4-methoxyphenyl)methyl]sulfamoyl}[1,1′-biphenyl]-4-yl 2-chlorobenzoate;
• (11) 4′-{[(4-methoxyphenyl)methyl]sulfamoyl}[1,1′-biphenyl]-4-yl 3-nitrobenzoate;
• and
• (12) 4′-{[(4-methoxyphenyl)methyl]sulfamoyl}[1,1′-biphenyl]-4-yl 2,4-dichlorobenzoate.