Method of synthesizing acyl ester using microreactor

A method of synthesizing acyl ester using a microreactor, comprising:

• injecting an acyl chloride, an alcohol, an organic solvent, an organic base and a calcium oxide into a microreactor by a mixed jet flow,
• wherein the acyl chloride is injected into the microreactor through a first channel of the microreactor;
• wherein the calcium oxide is injected into the microreactor through a second channel of the microreactor;
• and
• wherein each of the alcohol, the organic base and the organic solvent is independently injected into the microreactor through the second channel of the microreactor after being mixed with the calcium oxide, or injected into the microreactor through the first channel of the microreactor after being mixed with the acyl chloride, and a jet flow velocity ratio of the first channel to the second channel is 6 to 60.