Non-ionic surfactants and methods of making and using the same
AssigneeLife Technologies Corporation
InventorsPremchendar Nandhikonda, Yi-Zhen Hu, Krishnamurthy Nacharaju, Yexin Wu
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Abstract
Disclosed herein are aspects of a compound according to Formula I The compounds are useful as surfactants and can be used in applications for which a surfactant is indicated. The disclosed compounds are biodegradable and do not form toxic by-products when degraded. As such, the disclosed compounds can be used as replacements for current surfactants, such as current octylphenol ethoxylates (OPEs) and nonylphenol ethoxylates (NPEs) that have toxic effects when degraded. Also disclosed are aspects of a method for making the compounds and methods for using the compounds in cell assays.
Claims20
A compound having a structure according to Formula I
- wherein:
- R1 is a hydrophilic group;
- R2 is a lipophilic group;
- each R3 independently is C1-6alkyl, —O—C1-6alkyl, —O—C3-6cycloalkyl,
- PS is a polystyrene bead;
- n is from 0 to 8;
- each of R′ and R″ independently is H or C1-4alkyl, or R′ and R″ together with the carbon to which they are attached form C═O;
- m is from 0 to 6;
- X is O, N(Ra), C(═O), (C═O)N(Ra), C(═O)O, N(Ra) C(═O), OC(═O), or a bond;
- Y is a bond, O, or N(Ra);
- Linker is —(CH2)xO—, —(CH2)xC(═O)O—, —(CH2)xC(═O)N—, —(CH2)xOC(═O)—, or —(CH2)×NC(═O)—;
- x is 1, 2, 3, or 4;
- p is 0 or 1;
- and
- each Ra independently is H or C1-4alkyl.
A compound having a structure selected from the group consisting of:
Dependencies are inferred from the claim text.