Systems and methods for simulating cardiovascular fluid flow

A system for simulating cardiovascular fluid flow having a target fluid flow profile in a cadaver or a portion of the cadaver when connected thereto to form a fluid circuit, the target fluid flow profile comprising a target pulsatile flow component, the system comprising:

• a reservoir for storing a fluid;
• a pump for pumping the fluid;
• an input channel fluidly connected to the reservoir at an input channel inlet and fluidly connectable to the cadaver or the portion of the cadaver at an input channel outlet, the input channel outlet configured to connect to the cadaver or the portion of the cadaver at a first position in the cadaver or the portion of the cadaver;
• an output channel fluidly connectable to the cadaver or the portion of the cadaver at an output channel inlet and fluidly connected to the reservoir at an output channel outlet, the output channel outlet configured to connect to the cadaver or the portion of the cadaver at a second position, such that when the input and output channels are connected to the cadaver or the portion of the cadaver, the system forms a fluid circuit with the cadaver or the portion of the cadaver;
• a first valve in the input channel, the first valve operable between an open configuration and a closed configuration for modulating fluid flow in the input channel;
• a first sensor operatively connected to the input channel and configured to measure an input channel fluid flow parameter of the fluid in the input channel;
• a processor communicatively connected to the first valve and configured to:
• obtain input of the target fluid flow profile;
• control the first valve based on a preliminary first valve parameter;
• obtain input, from the first sensor, of the measured input channel fluid flow parameter in the input channel;
• adjust the preliminary first valve parameter until the measured input channel fluid flow parameter corresponds to the target pulsatile flow component.

A computer system for controlling a perfusion system, the perfusion system being configured to simulate cardiovascular fluid flow having a target fluid flow profile in a cadaver or a portion of the cadaver when connected thereto to form a fluid circuit, the computer system comprising:

• a processor configured to:
• obtain input of the target fluid flow profile, the target fluid flow profile having a target pulsatile flow component and a target systemic resistance component;
• control a first valve of the perfusion system based on a preliminary first valve parameter;
• obtain input, from a sensor of the perfusion system, of a measured input channel fluid flow parameter in an input channel of the perfusion system;
• adjust the preliminary first valve parameter until the measured input channel fluid flow parameter corresponds to the target pulsatile flow component;
• control a second valve of the perfusion system based on a preliminary second valve parameter, and obtain input from a sensor of a measured output channel fluid flow parameter in an output channel of the perfusion system;
• and
• adjust the preliminary second valve parameter until the measured output channel fluid flow parameter corresponds to the target systemic resistance component.

A method for perfusing a fluid in a cadaver or a portion of the cadaver using a system for simulating cardiovascular fluid flow having a target fluid flow profile, the method being executed by a processor of the system, the method comprising:

• obtaining input of the target fluid flow profile, the target fluid flow profile comprising a target pulsatile flow component;
• controlling a first valve of the system based on a preliminary first valve parameter;
• obtaining input, from a first sensor, of a measured input channel fluid flow parameter of an input channel;
• adjusting the preliminary first valve parameter until the measured input channel fluid flow parameter corresponds to the target pulsatile flow component.