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AssigneeUniversity of Galway
InventorsElizabeth SANDER, William HICKEY, Robert PENDLEBURY, Faisal SHARIF, Brendan MARRINAN, Tony O'HALLORAN
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A method of forming an implantable biomaterial comprising the steps of providing a polyether-diisocyanate prepolymer, reacting the prepolymer with one or more chain extender molecules typically including benzene 1,4-diol to form a mouldable polymer selected from a polyurethane or polyurethane-urea polymer or a polyurethane-urea block copolymer; placing the mouldable polymer into an implantable biomaterial shaped mould, and shaping and curing the mouldable polymer in the implantable biomaterial shaped mould to form the implantable biomaterial. An implantable biomaterial such as a heart valve leaflet is also disclosed.
An implantable biomaterial formed by:
An implantable biomaterial according to any preceding claim, in which the polyether is selected from the group consisting of:
An implantable biomaterial according to any preceding claim, in which the diisocyanate is a toluene diisocyanate.
An implantable biomaterial according to any preceding claim, in which:
An implantable biomaterial according to any preceding claim, in which a weight ratio of diisocyanate, polyether and chain extender in the block copolymer is 2-6:1-3:1-3.
An implantable biomaterial according to any preceding claim, in which the mouldable polymer is shaped in an implantable biomaterial shaped mould.
An implantable biomaterial according to any preceding claim, in which the mouldable polymer is cured in an implantable biomaterial shaped mould.
An implantable biomaterial according to any preceding claim, selected from a valve or valve leaflet, implantable conduit, heart assist device, stent, tissue prosthesis, catheter, balloon, shunt, or a fibre.
A method of forming a mouldable polymer comprising the steps of:
Dependencies are inferred from the claim text.