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AssigneeCapricor, Inc.
InventorsMinghao SUN, Kristi ELLIOTT, Mafalda CACCIOTTOLO, Yujia LI, Justin NICE, Michael LECLAIRE, Li-En HSIEH
Estimating the term…
The present disclosure relates to compositions and methods for vaccinating a subject against multiple SARS-CoV-2 variants that involves the making and delivery of extracellular vesicles expressing on their surface engineered spike protein and/or engineered nucleocapsid protein to the subject. The present invention also relates to compositions and methods for the design, preparation, manufacture, formulation, and/or use of spike-display and nucleocapsid-display vesicular vaccines designed to elicit strong humoral and cellular immune responses against multiple SARS-CoV-2 variants.
An immunogenic composition comprising an extracellular vesicle and a fusion protein, wherein said fusion protein comprises a SARS-CoV-2 polypeptide and an exosomal polypeptide, and wherein said composition does not comprise an adjuvant.
(canceled)
A method of immunizing a subject against a virus infection comprising administering to the subject an immunogenically effective dose of an immunogenic composition comprising an extracellular vesicle and a fusion protein, wherein said fusion protein comprises a SARS-CoV-2 spike protein polypeptide or a SARS-CoV-2 nucleocapsid protein polypeptide;
(canceled)
A synthetic fusion protein comprising a SARS-CoV-2 spike protein polypeptide or a SARS-CoV-2 nucleocapsid protein polypeptide, an exosomal polypeptide, and a linker polypeptide.
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Dependencies are inferred from the claim text.