Influenza b virus vaccines and uses thereof
AssigneeJanssen Vaccines & Prevention B.V.
InventorsFerdinand Jacobus MILDER, Jaroslaw JURASZEK, Johannes Petrus Maria LANGEDIJK
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Abstract
Provided herein are isolated mutant influenza hemagglutinin polypeptides, methods for providing isolated mutant influenza hemagglutinin polypeptides, methods of use of the isolated mutant influenza hemagglutinin polypeptides as a diagnostic or for the isolation of antibodies, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.
Claims25
An isolated mutant influenza hemagglutinin polypeptide comprising at least one stabilizing mutation in at least one region of instability (a)-(e) in the polypeptide, wherein the at least one stabilizing mutation comprises a substitution mutation at:
- (a) amino acid position 227, 229, and/or 238;
- and/or
- (b) amino acid positions 329 and/or 426;
- and/or
- (c) amino acid positions 384, 402, 472, and/or 476;
- and/or
- (d) amino acid positions 468, 471, 475 and/or 478;
- and/or
- (e) amino acid positions 235, 430, and/or 433;
- wherein the amino acid position corresponds to the amino acid position of SEQ ID NO:1.
Dependencies are inferred from the claim text.