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US 2026/0183373 A1Published application
Fusions with proteases and uses thereof
AssigneeGenentech, Inc.
InventorsGregory Alan LAZAR, Brandon LEONARD, Matthew G. ROMEI
Life of this patent
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Abstract
Provided herein are fusion proteins that involve an antibody that binds to a target fused to a protease that cleaves a substrate, and the target is in the proximity of the substrate. The target and the substrate in some cases are the same molecule. Methods of making and using such fusion proteins are also provided.
Claims13
A fusion protein comprising an antibody that binds to a target, wherein the antibody is fused to a protease that cleaves a substrate, wherein the target is in the proximity of the substrate.
2-3. (canceled)
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Dependencies are inferred from the claim text.