Allogeneic human plasma and platelet derived products and uses thereof
AssigneeConsano Bio, Inc.
InventorsEhab Mosa Alshamleh, Barbara Bennett, Karen Fu, Andrew James Hall, Vishwesh Ashok Patil, Jennifer Louise Schmitke, Teresa Leah Wright, Jennifer Newman, William Kane Grier
Life of this patent
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Abstract
Provided herein are compositions comprising allogeneic human plasma and platelet derived product, and methods for making the compositions and using the compositions as a therapeutic for example, in orthopedic indications.
Claims31
-125. (canceled)
A method of treating an orthopedic indication or an orthopedic injury in a human subject comprising administering to the human subject a pharmaceutical composition comprising an allogeneic human plasma and platelet derived product, wherein cells and cell debris are removed from the product, wherein the product comprises:
- (a) human plasma proteins comprising human serum albumin, immunoglobulins, and fibrinogen;
- and
- (b) human platelet proteins comprising platelet derived growth factor (PDGF)-AB at a concentration of about 20 ng/mL to about 160 ng/ml,
- wherein the total protein concentration of the composition is greater than 50 mg/mL and less than or about 500 mg/mL,
- thereby treating the orthopedic indication or the orthopedic injury in the human subject.
A method of treating pain associated with or resulting from an orthopedic indication or orthopedic injury in a human subject comprising administering to the human subject a pharmaceutical composition comprising an allogeneic human plasma and platelet derived product, wherein cells and cell debris are removed from the product, wherein the product comprises:
- (a) human plasma proteins comprising human serum albumin, immunoglobulins, and fibrinogen;
- and
- (b) human platelet proteins comprising platelet derived growth factor (PDGF)-AB at a concentration of about 20 ng/ml to about 160 ng/ml,
- wherein the total protein concentration of the composition is greater than 50 mg/mL and less than or about 500 mg/mL,
- thereby treating pain associated with or resulting from an orthopedic indication or orthopedic injury in the human subject.
Dependencies are inferred from the claim text.