N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases

A compound of Formula I:

• wherein:
• R1 and R2, independently from each other, are a substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted five- to ten-membered aryl, or substituted or unsubstituted C6-C16 aralkyl;
• or R1 and R2, together with a nitrogen atom to which they are attached, form a substituted or unsubstituted three- to ten-membered heterocycle;
• R3 and R4, independently from each other, are —H, -D, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted five- to ten-membered aryl, or substituted or unsubstituted C6-C16 aralkyl, halogen, —NO2, —CF3, —OR, or —SR;
• R5 is a substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted five- to ten-membered aryl, substituted or unsubstituted C6-C16 aralkyl, —OR, or —SR;
• R6 and R6′, independently from each other, are —H, -D, halogen, hydroxy, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted five- to ten-membered aryl, substituted or unsubstituted C6-C16 aralkyl, —OR or —SR;
• or R6, together with R8 or R6′, forms a substituted or unsubstituted C3-C6 cycloalkyl ring;
• R7 is one to four substituents on the aryl ring which, independently from each other, are —H, -D, halogen, —NO2, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted five- to ten-membered aryl, substituted or unsubstituted C6-C16 aralkyl, —OR, or —SR;
• X is O, S, or Se;
• Y, Z, and W, independently from each other, are carbon, nitrogen, sulfur, or oxygen;
• R8 is —H, -D, halogen, —NO2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C3-C5 cycloalkyl, substituted or unsubstituted five- to ten-membered aryl, substituted or unsubstituted C6-C16 aralkyl, —OR, or —SR;
• A is —CH2—, —CH2CH2—, —O—, —CH(—OH)—, —C(═O)—, —CHR—, —CR2— —CH(—OR)—, —S—, —SO—, —SO2—, or —N(R);
• and
• R is a substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted five- to ten-membered aryl, or substituted or unsubstituted C6-C16 aralkyl;
• or a pharmaceutically acceptable salt, racemate, diastereomer, enantiomer, regioisomer, hydrate, or solvate thereof.