Biodegradable Delivery Systems for Controlled Oral Delivery of Active Substances Using Microencapsulation and Multi-Trigger Mechanisms

Abstract

An oral delivery system for at least one biologically active substance includes an orally insertable substrate device having surfaces. Microcapsules including the at least one biologically active substance adhere to the substrate device. The microcapsules define a core encapsulating the at least one biologically active substance. The microcapsules include multi-layer shells including a water-soluble adhesive layer and a pH-responsive layer and the microcapsules are adhered to the substrate surfaces for controlled release triggered by pH and fluid flow. In preferred embodiments the orally insertable device is a pacifier, straw or cutlery.

Dependencies are inferred from the claim text.