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US 2026/0183237 A1Published application
Nanoemulsion without propylene glycol
AssigneeBiofrontera, Inc.
InventorsMontserrat FOGUET, Lars MÖLLMANN
Life of this patent
Estimating the term…
Abstract
The present invention relates to oil in water nanoemulsions which are essentially free of propylene glycol. The nanovesicle formulations are particularly stable in regard to shelf life at different storage temperatures.
Claims22
1-20. (canceled)
A formulation comprising:
- (a) a nanoemulsion, the nanoemulsion comprising:
- (i) at least one aqueous component;
- (ii) a carrier component, the carrier component comprising:
- (1) at least one lipophilic component,
- (2) at least one surfactant, and
- (3) at least one alcohol;
- and
- (b) 5-aminolevulinic acid or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof,
- wherein the formulation comprises essentially no propylene glycol and essentially no sorbitol;
- wherein the nanoemulsion comprises nanovesicles, wherein the nanovesicles have a size of 5 nm to 500 nm.
7 more elements
A formulation comprising:
- (a) a nanoemulsion, the nanoemulsion comprising:
- (i) at least one aqueous component;
- (ii) a carrier component, the carrier component comprising:
- (1) at least one lipophilic component,
- (2) at least one surfactant, and
- (3) at least one alcohol;
- and
- (b) 5-aminolevulinic acid or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof comprising an ester,
- wherein the formulation comprises essentially no propylene glycol and essentially no non-cyclic polyol having 2 to 5 carbon atoms;
- wherein the nanoemulsion comprises nanovesicles, wherein the nanovesicles have a size of 5 nm to 500 nm.
7 more elements
A formulation comprising
- (a) a nanoemulsion, the nanoemulsion comprising:
- (i) at least one aqueous component;
- (ii) a carrier component, the carrier component comprising:
- (1) at least one lipophilic component,
- (2) at least one surfactant, and
- (3) at least one alcohol;
- and
- (b) 5-aminolevulinic acid or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof comprising an ester,
- wherein the formulation comprises essentially no propylene glycol and essentially no sorbitol;
- wherein the nanoemulsion comprises nanovesicles, wherein the nanovesicles have a size of 5 nm to 200 nm after
- storage for at least six months at 2-25° C.;
- and/or
- storage for at least 24 months at 2-8° C.
10 more elements
Dependencies are inferred from the claim text.