Atropine-containing aqueous composition
OwnerDonald TAN, Roger BEUERMAN +5inventors
InventorsDonald TAN, Roger BEUERMAN, Hiroyuki ASADA, Kyohei TAKAHASHI, Koji SAKANAKA, Takashi MORIMOTO, Toyomi FUJISAWA
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Abstract
Disclosed herein is an aqueous composition comprising 0.001-0.1% (w/v) atropine or a salt thereof, a water-soluble polymer, and buffer (I), which is at a pH range of 6 or lower, wherein the buffer (I) is at least one selected from the group consisting of a phosphate buffer, an aminocarboxylate buffer, a carbonate buffer, an acetate buffer, a tartrate buffer, a borate buffer, and trometamol.
Claims16
1-44. (canceled)
A method for lowering mydriatic action of atropine or a salt thereof in an aqueous composition comprising 0.001%-0.1% (w/v) atropine or a salt thereof, a phosphate buffer and hydroxyethyl cellulose, which is at a pH range of 6 or lower.
A method for lowering mydriatic action of atropine or a salt thereof in an aqueous composition comprising 0.001%-0.1% (w/v) atropine or a salt thereof, 0.01%-1% (w/v) phosphate buffer, 0.02%-0.04% (w/v) citrate buffer and 0.1%-1% (w/v) hydroxyethyl cellulose, which is at a pH range of 6 or lower.
A method for lowering mydriatic action of atropine or a salt thereof in an aqueous composition comprising 0.001%-0.1% (w/v) atropine or a salt thereof, 0.01%-1% (w/v) phosphate buffer, 0.02%-0.04% (w/v) citrate buffer, 0.1%-1% (w/v) hydroxyethyl cellulose and 0.1%-5.0% (w/v) glycerin, which is at a pH range of 4-6, wherein the composition does not substantially comprise benzalkonium chloride.
Dependencies are inferred from the claim text.