Catheter with electroporation and fluid delivery features

A method comprising:

• advancing a distal portion of a catheter into a heart of a patient;
• tracking a location of the distal portion in the heart using one or more position sensors;
• advancing the distal portion further into a coronary sinus of the patient;
• preventing a flow of fluid including blood from flowing in a proximal direction;
• delivering a therapeutic fluid via the distal portion of the catheter;
• and
• applying pulsed field energy to induce reversible electroporation of tissue around the distal portion of the catheter.

A method comprising:

• inserting an elongate shaft assembly into an anatomical structure within a cardiovascular system of a patient, the elongate shaft assembly having a distal portion with an end effector, the end effector having a plurality of electrodes extending angularly about the distal portion of the shaft assembly and spaced longitudinally apart from each other along the distal portion of the shaft assembly, the shaft assembly further including a tip member positioned distal to the end effector, the tip member being more flexible than the distal portion of the shaft assembly;
• occluding an anatomical passageway in which the end effector is inserted;
• administering a therapeutic agent via the shaft assembly;
• selecting one or more electrodes of the plurality of electrodes to transmit pulses of electrical energy;
• and
• activating the one or more selected electrodes to transmit pulses of electrical energy sufficient to induce electroporation of cells of anatomical tissue of the anatomical passageway.