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OwnerDanny JONIGK, Florian LÄNGER +2inventors
InventorsDanny JONIGK, Florian LÄNGER, Helge STARK, Mark KÜHNEL
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The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of a pulmonary dysfunction in a subject. The method is based on the determination of the level of a panel of biomarkers selected from TM4SF18, TRGV9, ADORA2A, H963, IRF2, TNFSF14, TRIB1, SMAD3, TSLP, SLAMF8, THBS1, SOD1, HAS2, TLR2, THBD, TRA, TFEC, SPHK1, COL3A1, Elastin, IL6R, SN, TEK, SOX7, CXCL9, CXCL10, SLC38A6, SLC15A3, TGFA, SLPI, VWF, TLR8, TGFB1, CXCR6, CCL24, PD1, PLA1A, TRD, CTLA4, MMP9, CD301, PDL1, PDL2, TGFB1, CXCR6, CCL24, PD1, PLA1A, TRD, CTLA4, MMP9, and CD301. The new biomarker panels of this invention allow diagnosing and even stratifying various pulmonary dysfunctions in a subject, and even allow early detection of Chronic lung allograft dysfunction (CLAD). Furthermore provided are diagnostic kits for performing the methods of the invention.
A method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of a pulmonary dysfunction in a subject, comprising the steps of:
A method for assessing the risk of developing a pulmonary dysfunction in a subject, said method comprising the steps:
A method for evaluating the treatment success of a patient who received a therapy for treating pulmonary dysfunction, comprising
Dependencies are inferred from the claim text.