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US 2026/0177541 A1Published application
Acoustic separation of a test sample
AssigneeInstrumentation Laboratory Company
InventorsSHANKAR BALASUBRAMANIAN, NAM PHAN, LARA ADIB, YU WANG, Nicholas Vanderslice
Life of this patent
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Abstract
An example system includes a detector configured to detect a value that is based on a hematocrit of a test sample containing plasma and red blood cells, a fluidic channel configured to hold the test sample, and an acoustic transducer configured to apply acoustic waves to the fluidic channel to separate the plasma from the red blood cells in the fluidic channel. The acoustic waves have at least one of an amplitude, a frequency, or a duration that is based on the value.
Claims20
A system comprising:
- a detector configured to detect a value that is based on a hematocrit of a test sample comprised of plasma and red blood cells;
- a fluidic channel configured to hold the test sample;
- and
- an acoustic transducer configured to apply acoustic waves to the fluidic channel to separate the plasma from the red blood cells in the fluidic channel, the acoustic waves having at least one of an amplitude, a frequency, or a duration that is based on the value.
1 more element
A method comprising:
- determining a value based on a hematocrit of a test sample comprised of plasma and red blood cells;
- applying acoustic waves to a fluidic channel containing the test sample to separate the plasma from the red blood cells, at least one of an amplitude, a frequency, or a duration of the acoustic waves applied to the fluidic channel being based on the value;
- performing optical detection on the plasma;
- and
- determining hemolysis of the test sample based on a result of the optical detection.
2 more elements
A system comprising:
- a detector configured to detect a value that is based on a hematocrit of a test sample comprised of plasma and red blood cells;
- a fluidic channel configured to hold the test sample;
- an acoustic transducer configured to apply acoustic waves to the fluidic channel to separate the plasma from the red blood cells in the fluidic channel;
- and
- a control system configured to control the acoustic transducer to produce acoustic waves that sweep over a range of frequencies, the range of frequencies being based on the hematocrit.
2 more elements
Dependencies are inferred from the claim text.