Compression and heat-assisted production of silk-based materials
OwnerDavid L. Kaplan, Fiorenzo G. Omenetto +2inventors
InventorsDavid L. Kaplan, Fiorenzo G. Omenetto, Chunmei Li, Chengchen Guo
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Abstract
In some embodiments, the present disclosure provides methods including the steps of (i) providing silk fibroin material comprising substantially amorphous structure, and (ii) applying at least one of elevated temperature and elevated pressure to the silk fibroin material to form a silk fibroin article, wherein the applying induces fusion between at least a portion of the silk fibroin and structural change of fibroin in the silk fibroin material. In some embodiments, the present disclosure also provides silk fibroin articles made in accordance with the methods disclosed herein.
Claims39
A method comprising:
- (i) providing silk fibroin material comprising amorphous structure;
- and
- (ii) applying an elevated temperature and an elevated pressure to the silk fibroin material to form a silk fibroin article, wherein the applying induces fusion between at least a portion of the silk fibroin and structural change of fibroin in the silk fibroin material,
- wherein the elevated pressure is at least 100 MPa,
- wherein the elevated temperature is applied to the silk fibroin material after the elevated pressure is applied.
A method comprising:
- (i) selecting an elevated temperature and an elevated pressure to produce a desired silk fibroin article of a desired crystallinity and desired material properties;
- and
- (ii) applying the elevated temperature and the elevated pressure to a silk fibroin material comprising substantially amorphous structure to form a silk fibroin article, wherein the silk fibroin article has the desired crystallinity and the desired material properties,
- wherein the elevated pressure is at least 100 MPa,
- wherein the elevated temperature is applied to the silk fibroin material after the elevated pressure is applied.
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Dependencies are inferred from the claim text.