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US 2026/0176623 A1Published application
Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions
AssigneeEmpirico Inc.
InventorsOmri GOTTESMAN, Shannon BRUSE, Brian CAJES, David LEWIS, David ROZEMA
Life of this patent
Estimating the term…
Abstract
Molecules for inhibiting arachidonate 15-lipoxygenase (ALOX-15) gene products including dsRNA (dsRNA) agents such as small interfering RNAs (siRNAs) for therapeutic use, additionally, methods to inhibit the expression of a target gene by administering these agents for the treatment of diseases involving ALOX-15 gene products.
Claims21
1-103. (canceled)
A pharmaceutical composition comprising an siRNA molecule comprising a sense strand and an antisense strand, which targets SEQ ID NO:
- 5357 and when administered to a patient in an effective amount reduces an eosinophil count in the patient, reduces airway symptoms in the patient, reduces a number or size of nasal polyps in the patient, improves nasal inspiratory peak flow in the patient, or improves a sense of smell in the patient;
- wherein the siRNA comprises a modification comprising a modified nucleoside and/or a modified internucleoside linkage, the pharmaceutical composition comprises a pharmaceutically acceptable carrier, and the patient comprises nasal polyposis, chronic sinusitis, allergic rhinitis, or NSAID-exacerbated respiratory disease, or a combination thereof.
Dependencies are inferred from the claim text.