US 2026/0176601 A1Published application

Dna polymerase variants

AssigneeCodexis, Inc.

InventorsEricka Bermudez, David Elgart, Jason Fell, Michelle Li, Marissa Greene MacAvoy, Mathew G. Miller, Vesna Mitchell, Jovana Nazor, Kevin S. Nelson, Scotty Walker, Anthony S. Muerhoff, Shouqiang Cheng, David Christensen, Alicia Case, Christopher Marohnic, Nazanin Nahrjou

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Abstract

The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.

Claims79

Dependent claims

An engineered DNA polymerase, or a functional fragment thereof, comprising an amino acid sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or more sequence identity to a reference sequence corresponding to residues 12 to 844 of SEQ ID NO:

2, 220, 226, 272, 328, 546, 710, or 1208, or to a reference sequence corresponding to SEQ ID NO:
2, 220, 226, 272, 328, 546, 710, or 1208, wherein the amino acid sequence comprises one or more mutations relative to the reference sequence corresponding to residues 12 to 844 of SEQ ID NO:
2, 220, 226, 272, 328, 546, 710, or 1208, or relative to the reference sequence corresponding to SEQ ID NO:
2, 220, 226, 272, 328, 546, 710, or 1208.

1 more element

Dependencies are inferred from the claim text.