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US 2026/0176598 A1Published application
Expression construct
AssigneeQuell Therapeutics Limited
InventorJenny MCGOVERN
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Abstract
An expression construct, a nucleic acid or vector or cell comprising said expression construct, and various uses of said expression construct, nucleic acid, vector or cell is disclosed herein. Particularly, an expression construct comprising a PGK promoter operably linked to (i) a first nucleotide sequence encoding a chimeric antigen receptor (CAR), and (ii) a second nucleotide sequence encoding a FOXP3 polypeptide, wherein the first nucleotide sequence is located upstream of the second nucleotide sequence, is provided.
Claims22
An expression construct comprising a PGK promoter operably linked to:
- (i) a first nucleotide sequence encoding a chimeric antigen receptor (CAR);
- and
- (ii) a second nucleotide sequence encoding a FOXP3 polypeptide;
- wherein the first nucleotide sequence is located upstream of the second nucleotide sequence.
1 more element
Dependencies are inferred from the claim text.