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US 2026/0176577 A1Published application
Prostaglandin e receptor 4 antagonists
AssigneeNational Health Research Institutes
InventorsLun Kelvin Tsou, Hua-Jung Li, Guang-Hao Niu
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Abstract
The compounds of Formula (I): Each variable is defined. Also disclosed is method of producing secresomes enriched for proteins or mRNAs using such compounds.
Claims18
A compound of Formula (I):
- in which
- R1 is H or NH2, or R1 and R2, together with the nitrogen atom they bond to, form a heterocycloalkyl ring;
- R2 is a bond, CH2, (CH2)2, (CH2)3, (CH2)4, (CH2)5, (CH2)4CH(COOH), or (CH2)6;
- X is a bond, C(═NH), O, NH, NR3′, N(NH2), NHC(O), or NHC(S), R3′ being C1-C6 alkyl;
- and
- R3 is phosphonate, phosphonic, carboxylic, C3-C6 alkyl, C1-C6 alkoxy, C3-C10 cycloalkyl, 3- to 10-membered heterocycloalkyl, amino, aryl, or heteroaryl.
3 more elements
Dependencies are inferred from the claim text.