Bioreactor Systems and Methods of Operating Same
AssigneeNational Resilience, Inc.
InventorsHuanchun Cui, Thomas Erdenberger, Thomas Ransohoff
Life of this patent
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Abstract
The systems and methods disclosed herein can generate product from cells using a bioreactor system. The bioreactor system can include a centrifuge. The bioreactor system can use a centrifuge to improve product yield. The centrifuge can be used to separate content received from the bioreactor. The separated content can be diverted back to the bioreactor, or filtered and/or collected.
Claims36
A system comprising:
- a centrifuge in fluidic communication with a bioreactor, wherein the centrifuge is configured to receive and separate content from the bioreactor into a first portion and a second portion, wherein a composition of the first portion is different from a composition of the second portion;
- a first fluidic pathway configured to transfer the first portion from the centrifuge back to the bioreactor;
- and
- a second fluidic pathway configured to transfer the second portion from the centrifuge to a filtration unit.
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A method comprising:
- performing centrifugation on content received from a bioreactor, thereby separating the received content into a first portion and a second portion, wherein a composition of the first portion is different from a composition of the second portion;
- and
- transferring the first portion back to the bioreactor, and transferring the second portion to a filtration unit.
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Dependencies are inferred from the claim text.