Anti-her2/trop2 antibodies and uses thereof
AssigneeBright Biologics LLC
InventorsMing Yang, Hongyan Zhong
Life of this patent
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Abstract
This disclosure relates to anti-HER2 antibodies or antigen binding fragments thereof, anti-TROP2 antibodies or antigen binding fragments thereof, antigen-binding protein constructs (e.g., bispecific antibodies or antigen-binding fragments thereof) that specifically bind to two different antigens (e.g., HER2 and TROP2), and antibody drug conjugates.
Claims31
An antibody or antigen-binding fragment thereof that specifically binds to HER2 (human epidermal growth factor receptor 2), comprising:
- a heavy-chain antibody variable domain (VHH) comprising complementarity determining regions (CDRs) 1, 2, and 3,
- wherein the CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
- 22, 23, and 24, respectively.
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-9. (canceled)
An antibody or antigen-binding fragment thereof that specifically binds to TROP2 (Tumor-associated calcium signal transducer 2), comprising:
- a heavy-chain antibody variable domain (VHH) comprising complementarity determining regions (CDRs) 1, 2, and 3,
- wherein the CDRs 1, 2, and 3 amino acid sequences are one of the following:
- (1) the CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
- 25, 26, and 27, respectively;
- (2) the CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
- 28, 29, and 30, respectively;
- and
- (3) the CDRs 1, 2, 3 amino acid sequences are set forth in SEQ ID NOs:
- 31, 32, and 33, respectively.
-17. (canceled)
-49. (canceled)
A polypeptide complex, comprising
- (a) a first polypeptide comprising from N-terminus to C-terminus:
- a VHH2, a first hinge region, a first CH2, a first CH3, and VHH1;
- and
- (b) a second polypeptide comprising from N-terminus to C-terminus:
- a VHH4, a second hinge region, a second CH2, a second CH3, and a VHH3,
- wherein the VHH1 and the VHH3 specifically bind to HER2, and the VHH2 and the VHH4 specifically bind to TROP2.
-54. (canceled)
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-65. (canceled)
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-91. (canceled)
Dependencies are inferred from the claim text.