Activation Inducible Antigen Receptors for Adoptive Immunotherapy
OwnerMaria Themeli, Afroditi Katsarou +1inventors
InventorsMaria Themeli, Afroditi Katsarou, Georgios Kladis
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Abstract
The invention relates to an inducible chimeric co-stimulatory receptor (CCR) comprising an intracellular T cell activation dependent localization domain. The invention further relates to an immune cell expressing the inducible CCR, a nucleic acid molecule encoding said inducible CCR, and to a pharmaceutical composition, comprising said immune cell or said nucleic acid molecule. The invention further relates to a method of producing said immune cell and to a method of treating a malignancy, comprising providing immune cells expressing the inducible CCR to a patient in need thereof.
Claims20
An inducible chimeric co-stimulatory receptor (CCR) comprising:
- an antigen specific binding domain;
- a transmembrane domain;
- one or more intracellular co-stimulatory signaling domains;
- and
- an intracellular CTLA4 domain as an intracellular T cell activation dependent domain.
Dependencies are inferred from the claim text.