Specific binding molecules for fibroblast activation protein (fap)
AssigneeNavigo Proteins GmbH
InventorsEva Bosse-Doenecke, Manja Gloser-Braeunig, Jonathan Lotze, Anja Katzschmann, Ina Coburger, Heike Boecker, Hanna Bobolowski
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Abstract
The present invention relates to new ubiquitin derived molecules that bind specific to Fibroblast Activation Protein (FAP). The invention further refers to FAP binding ubiquitin derived molecules (Affilin®) proteins that further comprise a diagnostically or therapeutically active component. Further aspects of the invention cover such FAP binding proteins for a use in medicine, for example, for a use in diagnosis (including imaging) or treatment of FAP related tumors.
Claims17
A protein comprising an amino acid sequence of at least 90% identity to any one of SEQ ID NOs:
- 1-12 and 15-27, wherein the protein has a specific binding affinity for human Fibroblast Activation Protein (hFAP) of less than 50 nM.
The protein of claim [ ], wherein the protein further comprises at least one therapeutically active moiety.
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Dependencies are inferred from the claim text.