Stapled and stitched polypeptides and uses thereof
AssigneePresident and Fellows of Harvard College
InventorsGregory L. VERDINE, Gerard HILINSKI
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Abstract
The present invention provides stapled polypeptides of the Formulae (I) and (VI): and salts thereof; wherein the groups ; R1a, R1b, R1c, R2a, R3a, R2b, R3b, R4a, R4b, RA, RZ, L1a, L1b, L2, L3, XAA, v, w, p, m, s, n, t, and q are as defined herein. The present invention further provides methods of preparing the inventive stapled polypeptides from unstapled polypeptide precursors. The present invention further provides pharmaceutical compositions comprising a stapled polypeptide of Formula (I) or (VI), and methods of using the stapled peptides. The present invention also provides modifications of the staples post ring closing metathesis.
Claims4
1-17. (canceled)
A compound, wherein the compound is
- or a salt thereof.
A compound wherein the compound is
- or a salt thereof.
A compound wherein the compound is
- or a salt thereof.
Dependencies are inferred from the claim text.