Tricyclic sulfones as ror gamma modulators
OwnerQingjie Liu, T.G. Murali Dharinventors
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Abstract
There are described RORγ modulators of the formula (I), or stereoisomers, pharmaceutically acceptable salts thereof, wherein all substituents are defined herein.
Claims4
A method of treating a disease or disorder selected from an autoimmune disease or disorder, asthma, an allergic disease or disorder, a metabolic disease or disorder, and cancer in a subject, the method comprising administering to the subject a therapeutically-effective amount of a compound according toa compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein R is:
A method of treating a disease or disorder selected from an autoimmune disease or disorder, asthma, an allergic disease or disorder, a metabolic disease or disorder, and cancer in a subject, the method comprising administering to the subject a therapeutically-effective amount of a compound according to a compound of Formula (II)
- which is (S)-N-((6aS,7R,9aS)-9a-((4-fluorophenyl)sulfonyl)-3-(perfluoropropan-2-yl)-6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[f]quinolin-7-yl)-2-hydroxy-2-methyl-3-(methylsulfonyl)propanamide.
Dependencies are inferred from the claim text.