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AssigneeThe Regents of the University of Colorado, a body corporate
InventorsCorey Neu, Jeanne Barthold
Estimating the term…
Particulated and reconstituted tissues comprising small, densely packed tissue microparticles encapsulated in a tissue specific promoting gel packed at a percolation threshold that can be transplanted into damaged tissue thereby facilitating regeneration following trauma to the tissue. The engineered microparticle construct for tissue replacement and repair, as taught herein, provides numerous benefits including (1) encouraging a regenerative response in damaged tissue regions, (2) mimicking the structural support of native tissue, (3) establishing an environment that promotes attachment, migration, and differentiation of infiltrating stem cells, and (4) providing a source of growth factors and other anti-catabolic growth factors and cytokines. Tissue specific microparticles packed together at, or past, their percolation threshold will provide the necessary mechanical environment and to best recapitulate and integrate with native tissue. The packing of microparticles, derived from the ECM of native tissue to a concentration past the percolation point will yield both the necessary biochemical and biomechanical properties necessary for reconstituting a specific tissue.
1-36. (canceled)
A method of producing a composite biomaterial for tissue regenerative medicine comprising the steps of:
The method of producing a composite biomaterial for tissue regenerative medicine according to claim 48 further comprising the step of adding one or more soluble factors to form a suspension within the resin.
A method of producing a composite biomaterial for tissue regenerative medicine comprising a gel resin of a thiolated hyaluronic acid and poly(ethylene glycol) diacrylate in combination with tissue microparticles, comprising the steps of:
Dependencies are inferred from the claim text.