Production method of intermediate for radiopharmaceutical composition, and purification kit for intermediate for radiopharmaceutical composition
AssigneeNational Institutes for Quantum Science and Technology
InventorsYukie YOSHII, Hiroki MATSUMOTO
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Abstract
Production of a higher-purity intermediate of a radioactive antibody drug. The production method of the present invention includes: an adsorption step of adsorbing a composition containing the intermediate onto a stationary phase for hydrophobic chromatography; and a purification step of eluting the intermediate from the stationary phase. The intermediate is a complex of a 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA) and an anti-epidermal growth factor receptor antibody (anti-EGFR antibody).
Claims11
A method for producing an intermediate of a radiopharmaceutical composition, comprising:
- an adsorption step of adsorbing a composition containing the intermediate onto a stationary phase for hydrophobic chromatography;
- and
- a purification step of eluting the intermediate from the stationary phase by passing an acetate buffer through the stationary phase, the acetate buffer serving as an eluent and containing at least one stabilizer selected from the group consisting of neutral amino acids and polysorbates,
- wherein the intermediate is a complex of a 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA) and an anti-epidermal growth factor receptor antibody (anti-EGFR antibody).
A kit for purification of an intermediate of a radiopharmaceutical composition, comprising:
- a stationary phase for hydrophobic chromatography;
- and
- an eluent containing at least one stabilizer selected from the group consisting of neutral amino acids and polysorbates,
- wherein the intermediate is a complex of a 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA) and an anti-epidermal growth factor receptor antibody (anti-EGFR antibody).
Dependencies are inferred from the claim text.