Compositions and methods of treating, preventing, or delaying the progression of neurodegenerative disease
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsFei Yin, Weihua Wang
Life of this patent
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Abstract
Methods and compositions for manipulating metabolism in astrocytes to improve astrocytic and neuronal function, as well as individual pathology hallmarks and symptoms during the development of neurodegeneration by increasing PPARα expression and activity specifically in astrocytes within the central nervous system to treat a variety of neurodegenerative conditions including but not limited to conditions involving neuronal lipid dysregulation, oxidative damage, accumulation of β-amyloid or other protein aggregates, dementia, and motor dysfunction. Also provided are methods of treating peripheral metabolic dysfunction associated with neurodegenerative conditions.
Claims20
A method of treating or delaying the onset of or preventing a neurodegenerative disease in a subject in need thereof, the method comprising administering a viral vector comprising an astrocyte-specific promoter operatively linked to at least a portion of a PPARA gene to the subject, wherein the viral vector upregulates the expression of PPARα to promote lipid metabolism selectively inside of astrocytes in the central nervous system.
A method of treating peripheral al metabolic dysregulation associated with neurodegenerative disease in a subject in need thereof, the method comprising administering a viral vector comprising an astrocyte-specific promoter operatively linked to at least a portion of a PPARA gene to a hypothalamus of a subject diagnosed with a neurodegenerative disease, wherein the viral vector upregulates the expression of PPARα to promote lipid metabolism in the hypothalamus of the subject, thereby indirectly altering downstream lipid metabolism in at least a peripheral portion of the subject.
Dependencies are inferred from the claim text.