Method for delivery of an agent across biological barriers
OwnerHsin-Hou CHANG, Der-Shan SUNinventors
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Abstract
The present disclosure provides a protein-vesicle conjugate, comprising one or more secretory proteins or a fragment thereof expressed on or conjugated to a surface of a vesicle and optionally an agent, and a method for delivery of an agent with the protein-vesicle conjugate across a biological barrier to a cell and tissue containing the cell.
Claims19
A method for delivery of an agent across a biological barrier to a cell and/or a tissue containing the cell, comprising contacting a protein-vesicle conjugate or a pharmaceutical comprising the protein-vesicle conjugate with a cell and/or a tissue of a subject, wherein the protein-vesicle conjugate comprises:
- (a) one or more secretory proteins or a fragment thereof expressed on or conjugated to a surface of a vesicle, and/or an antibodies specific to the one or more secretory proteins or the fragment thereof and expressed on or conjugated to the surface of the vesicle;
- and
- (b) an agent embedded in the vesicle.
Dependencies are inferred from the claim text.