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US 2026/0174872 A1Published application
Cyclodextrin acid base solubilization of poorly water-soluble small molecules
AssigneeSt. John's University
InventorsMimansa Goyal, Vivek Gupta
Life of this patent
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Abstract
A composition contains a BCS Class II or IV drug that is acid-base solubilized with a pharmaceutically acceptable acid, and which is complexed with β-cyclodextrin. The β-cyclodextrin complexed drug exhibits enhanced bioavailability. The drug may be formulated for oral administration and/or to exhibit rapid release when administered. Preferable compositions may contain no crosslinked or polymerized non-active components.
Claims15
A composition, comprising:
- a BCS Class II or IV drug that is acid-base solubilized with a pharmaceutically acceptable acid, and which is complexed with β-cyclodextrin, wherein
- the BCS Class II or IV drug exhibits enhanced bioavailability.
Dependencies are inferred from the claim text.