Thixotropic delivery systems
AssigneeThe University of Montana
InventorMonica Serban
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Abstract
The present disclosure provides compositions comprising a hydrolyzed tetraethyl orthosilicate (TEOS) and at least one macromolecule selected from the group consisting of hyaluronan and silk fibroin and methods of making thereof. The disclosure further provides methods of using the composition for delivery of an active agent and for treatment of diseases and disorders. Also provided are delivery devices and kits comprising the disclosed composition.
Claims56
A composition comprising:
- a) a hydrolyzed tetraethyl orthosilicate (TEOS);
- b) at least one macromolecule selected from the group consisting of hyaluronan and silk fibroin;
- and
- c) water or a biocompatible buffer.
The composition of any of claims 1-3, wherein the composition comprises about 0.1% to about 20% (w/v) of the at least one macromolecule, based on volume of hydrolyzed TEOS.
A method for the delivery of at least one active agent comprising providing at least one active agent in a thixotropic hydrogel comprising:
- a) a hydrolyzed tetraethyl orthosilicate (TEOS);
- b) at least one macromolecule selected from the group consisting of hyaluronan and silk fibroin;
- and
- c) water or a biocompatible buffer.
Dependencies are inferred from the claim text.