Foot-and-mouth disease vaccine
AssigneesZoetis Services LLC, The United States of America as represented by the Secretary of Agriculture
InventorsPaul Joseph Dominowski, John Morgan Hardham, James Alan Jackson, Cyril Gerard Gay, Luis Leandro Rodriguez, Peter William Krug, Aida Elizabeth Rieder
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Abstract
Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 μg FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.
Claims21
An immunogenic composition comprising an antigen component and an adjuvant component, wherein
- a) the adjuvant component comprises an emulsion containing oil, a CpG containing immunostimulatory oligonucleotide, and at least one of:
- i) a polycationic polymer;
- or
- ii) a source of aluminum;
- and
- b) the antigen component comprises 0.5-10 μg of FMD (Foot-and-Mouth Disease) virus composition per dose,
- wherein the CpG containing immunostimulatory oligonucleotide comprises a 5′ TLR activation domain and at least two palindromic regions, one palindromic region being a 5′ palindromic region of at least 6 nucleotides in length and connected to a 3′ palindromic region of at least 8 nucleotides in length either directly or through a spacer.
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Dependencies are inferred from the claim text.