Methods and compositions of quaternary immunomodulatory nanoparticles for medical applications and immunotherapy
OwnerR. Holland CHENG, Chun-Chieh CHEN +1inventors
InventorsR. Holland CHENG, Chun-Chieh CHEN, Chin-Fu CHEN
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Abstract
The present disclosure provides a method of enhancing an immune response in a subject in need thereof, including administering an effective amount of an antigen with an immune modulator to the subject, wherein the immune modulator is a quaternary immunomodulatory nanoparticle (QIN). The present disclosure also provides the use of the QIN in the manufacture of a chimeric nanoparticle, a pharmaceutical composition and a medicament for treating a subject suffering from a cancer or virus infection.
Claims18
A method of enhancing an immune response in a subject in need thereof, the method comprising administering an effective amount of an antigen with an immune modulator to the subject, wherein the immune modulator is a quaternary immunomodulatory nanoparticle (QIN).
A chimeric nanoparticle comprising a QIN coupled and an epitope of a GMI protein.
A pharmaceutical composition comprising a QIN and a pharmaceutically acceptable carrier, vehicle, or diluent.
Dependencies are inferred from the claim text.