Immunogenic Compositions Containing Non-Natural Amino Acids for the Prevention and Treatment of Pneumococcal Infections
AssigneeInventprise, LLC
InventorSubhash V. Kapre
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Abstract
This invention relates to immunogenic compositions for the prevention and treatment of infection due to Streptococcus pneumoniae containing P4 peptide and/or detoxified pneumolysin protein conjugated to a T cell stimulating epitope as a contiguous peptide sequence. In particular, non-natural amino acid sequences inserted between the structures create points of conjugation that do not interfere with the generation of an effective immune response. This invention is also directed to method for the manufacture of these compositions and administration of these compositions to subjects.
Claims19
An immunogenic composition containing a contiguous amino acid sequence comprising:
- an antigenic portion comprised of part or all of a PspA (pneumococcal surface protein A) peptide, a P4 (functional portion PspA) peptide, and/or a dPly (detoxified pneumolysin) peptide:
- a T cell stimulating portion;
- and
- one or more non-naturally occurring amino acids (nnAA) between the antigenic portion and the T cell stimulating portion.
An immunogenic composition containing a contiguous amino acid sequence comprising:
- an antigenic portion containing a dPly peptide coupled to a P4 peptide;
- and
- one or more non-naturally occurring amino acids.
Dependencies are inferred from the claim text.