Polymers for intracellular delivery of polynucleotides
AssigneesNational University of Singapore, Shanghai Jiao Tong University
InventorsXiaoyuan Chen, Pei Huang, Hongzhang Deng, Yongfeng Zhou
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Abstract
The present invention provides an ionizable polymer comprising a constitutional unit according to formula (I). wherein R1 and R2 are as defined in the specification. The ionizable polymer of the invention finds use in the intracellular delivery of polynucleotides in vitro and in vivo. The present invention also provides compositions comprising the ionizable polymer of the invention and a polynucleotide. The compositions disclosed herein find utility as medicaments, in particular as medicaments for the prevention or treatment of an infectious disease, a cancer, or a protein-deficiency disease.
Claims24
An ionizable polymer comprising a constitutional unit according to formula (I):
- wherein
- R1 represents a covalent bond or a linking moiety derived from a polyalkylene glycol;
- and
- R2 represents a linear or branched aliphatic hydrocarbyl or a linear or branched fluorinated aliphatic hydrocarbyl group.
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-29. (canceled)
Dependencies are inferred from the claim text.