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US 2026/0174785 A1Published application
Mitochondria-targeted atovaquone: a more potent and more effective antitumor, antimicrobial, and antimalarial drug
AssigneesThe Medical College of Wisconsin, Inc., Aix-Marseille Universite
InventorsBalaraman Kalyanaraman, Gang Cheng, Micael Joël Hardy
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Abstract
The present invention provides novel mitochondria-targeted Atovaquone compounds (Mito-ATO), a mitochondria-targeted derivative of Atovaquone, and methods of using such compounds. Methods of treating cancer using mito-ATO are also provided. Methods of enhancing an anti-tumor immune response by administering mito-ATO are further provided.
Claims14
A mito-ATO compound of formula
- wherein
- Cy is a cycloalkyl or aryl;
- and
- R is H, F, Br, or I.
1 more element
Dependencies are inferred from the claim text.