Aryl-containing amine compound, preparation method therefor and use thereof

A compound of formula (I) or a stereoisomer thereof, a geometric isomer thereof, a conformational isomer thereof, or a tautomer thereof, or a pharmaceutically acceptable salt thereof, a polymorph thereof, a solvate thereof, a hydrate thereof, or an isotopically labeled compound thereof:

• wherein:
• ring A is selected from the group consisting of a 4- to 10-membered heterocyclic ring and a C6-C10 aromatic ring fused 4- to 10-membered heterocyclic ring, wherein the 4- to 10-membered heterocyclic ring comprises 1-3 heteroatoms selected from the group consisting of N, O, and S;
• ring A is optionally substituted with one or more R5, wherein each R5 is independently selected from the group consisting of halogen, hydroxy, amino, cyano, carboxy, oxo, C1-C6 alkyl, halogenated C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkanoyl, carbamoyl (—CONH2), carbamoyl substituted with C1-C6 alkyl, amino substituted with one or two C1-C6 alkyl, amino substituted with one or two halogenated C1-C6 alkyl, amino substituted with one or two C1-C6 alkanoyl, C1-C6 alkoxycarbonyl, C3-C6 cycloalkyl, 4- to 10-membered heterocycloalkyl, C6-14 aryl, 5- to 10-membered heteroaryl, C6-C14 aryl C1-C6 alkyloxy, and 5- to 10-membered heteroaryl C1-C6 alkyloxy;
• ring B is a 3- to 10-membered carbocyclic ring;
• R1 and
• are attached to the same ring carbon atom in ring B;
• x is an integer of 0 to 2;
• R2 and R3 are each independently selected from the group consisting of hydrogen, C1-C6 alkyl, halogenated C1-C6 alkyl, C1-C6 alkoxy C1-C6 alkyl, hydroxy C1-C6 alkyl, C6-C14 aryl C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkanoyl, halogenated C1-C6 alkanoyl, C3-C6 cycloalkyl C1-C6 alkanoyl, C6-C14 aryl C1-C6 alkanoyl, C1-C6 alkylsulfonyl, C1-C6 alkylsulfinyl, and C3-C6 cycloalkyl C1-C6 alkyl;
• or, R2 and R3, together with the nitrogen atom to which they are attached, form a 3- to 9-membered heterocycloalkyl, which optionally comprises one or more additional nitrogen or oxygen atoms in the ring and is optionally substituted with one or more C1-C6 alkyl;
• R1 is selected from the group consisting of C6-C14 aryl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocyclyl, C6-C10 aryl fused 4- to 10-membered carbocyclic ring (e.g., indanyl), and C6-C10 aryl fused 4- to 10-membered heterocyclic ring;
• the C6-C14 aryl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocyclyl, C6-C10 aryl fused 4- to 10-membered carbocyclic ring, and C6-C10 aryl fused 4- to 10-membered heterocyclic ring are optionally substituted with one or more R6;
• R6 are each independently selected from the group consisting of halogen, hydroxy, sulfhydryl, cyano, carbamoyl (NH2CO—), sulfamoyl (NH2SO2—), C1-C6 alkyl, halogenated C1-C6 alkyl, hydroxy C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, C3-C6 cycloalkyl substituted with C1-C3 alkyl, C3-C6 cycloalkoxy substituted with C1-C3 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, halogenated C1-6 alkoxy, C3-C6 cycloalkyl C1-C6 alkoxy, C1-C6 alkanoyloxy, C6-C14 aryl, 5- to 10-membered heteroaryl, C6-C14 aryl C1-C6 alkoxy, and 5- to 10-membered heteroaryl C1-C6 alkoxy;
• m is an integer of 0 to 3;
• and
• R4 is attached to any carbon atom of ring B other than the carbon atom to which both R1 and
• are attached, and R4 are each independently selected from the group consisting of hydroxy, halogen, and C1-C6 alkyl.