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US 2026/0174738 A1Published application
Compositions and methods for inhibiting type i collagen production
AssigneeThe Florida State University Research Foundation, Inc.
InventorBranko Stefanovic
Life of this patent
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Abstract
Nano-entity compositions composed of a plurality of self-associated compounds of Formula 1 and/or Formula 2 have antifibrotic properties. Such compositions may be used to inhibit type I collagen synthesis.
Claims22
A composition comprising a pharmaceutical dosage form including a nano-entity composed of a plurality of self-associated compounds of a first formula
- wherein:
- R1 and R2 are independently selected from the group consisting of H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkoxy group, a hydroxy group, a carboxy group, an acyl group, a nitro group, a phosphor group, a halo group, a sulfo group, an ester group, an ether group, an amine group, and a combination thereof;
- wherein the pharmaceutical dosage form also includes a tautomer of the first formula.
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A method comprising:
- performing an acid catalyzed hydrolysis of a first formula
- to form a tautomeric mixture of a second formula
- and a third formula
- and
- dissolving the tautomeric mixture in a solvent to form a nano-entity composed of a plurality of self-associated compounds of the second formula and the third formula;
- wherein R1 and R2 are independently selected from the group consisting of H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkoxy group, a hydroxy group, a carboxy group, an acyl group, a nitro group, a phosphor group, a halo group, a sulfo group, an ester group, an ether group, an amine group, and a combination thereof.
3 more elements
Dependencies are inferred from the claim text.