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US 2026/0174711 A1Published application
Methods of treating trigeminal nerve pain
AssigneeVanderbilt University
InventorJill M. Pulley
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Abstract
Provided are methods for treating trigeminal nerve pain in a subject in need thereof. The method may include administering to the subject by perineural injection of the trigeminal nerve a therapeutically effective amount of a composition comprising an alpha-2 adrenergic agonist, such as guanfacine. The composition may further comprise lidocaine.
Claims21
1-30. (canceled)
A method of treating trigeminal nerve pain in a subject, comprising:
- administering by perineural injection to a trigeminal nerve of the subject a therapeutically effective amount of a composition comprising guanfacine or a pharmaceutically acceptable salt thereof,
- wherein the subject is selected based on the presence of a single-nucleotide polymorphism in the ADRA2B gene.
A method of managing trigeminal nerve pain, comprising:
- (a) administering by perineural injection to a trigeminal nerve a composition comprising guanfacine and lidocaine;
- and
- (b) repeating the perineural administration after a period of time.
Dependencies are inferred from the claim text.