Aerosol composition

An aerosol composition comprising:

• a UPy-PEG polymer having hydrophobic hard blocks covalently bonded with hydrophilic soft blocks wherein the hydrophobic hard blocks comprise 2-ureido-4 [1H]-pyrimidinone (UPy) moieties and aliphatic spacers and the hydrophilic soft blocks comprise polyethylene glycol moieties;
• and
• a pharmaceutically acceptable carrier
• wherein the aerosol composition comprises:
• a viscosity of 1 to 500 mPa·s, preferably 1 to 100 mPa·s over a temperature range of 15 to 25° C. and a pH range of 8.5 to 14,
• a viscosity of 1 to 20 mPa·s, preferably 1 to 5 mPa·s over a temperature range of 35 to 50° C. and a pH range of 8.5 to 14,
• a viscosity of at least 100 mPa·s, preferably at least 1000 mPa·s over a temperature range of 35 to 40° C. and a pH range of 6 to 8,
• wherein the viscosity is measured at shear rate 1 s−1,
• wherein the aerosol composition is configured for use in a method of treatment or prevention of a disease of the peritoneal cavity, the treatment or prevention comprising administration of the aerosol composition to the peritoneal cavity by nebulization.