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US 2026/0174691 A1Published application
Nanoemulsion without propylene glycol
AssigneeBiofrontera, Inc.
InventorsMontserrat FOGUET, Lars MÖLLMANN
Life of this patent
Estimating the term…
Abstract
The present invention relates to oil in water nanoemulsions which are essentially free of propylene glycol. The nanovesicle formulations are particularly stable in regard to shelf life at different storage temperatures.
Claims20
1-20. (canceled)
A method of treating a dermatological disease in a subject in need thereof, comprising:
- topically administering to a diseased or affected area of the subject's skin a formulation, the formulation comprising:
- (a) a nanoemulsion, the nanoemulsion comprising:
- (i) at least one aqueous component;
- (ii) a carrier component, the carrier component comprising:
- (1) at least one lipophilic component,
- (2) at least one surfactant, and
- (3) at least one alcohol;
- and
- (b) 5-aminolevulinic acid or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof,
- wherein the formulation comprises essentially no propylene glycol and essentially no sorbitol;
- and
- irradiating the diseased or affected area of the subject's skin to which the formulation was administered with light to treat the dermatological disease.
9 more elements
A method of treating a dermatological disease in a subject in need thereof, comprising:
- topically administering to a diseased or affected area of the subject's skin a formulation, the formulation comprising
- (a) a nanoemulsion, the nanoemulsion comprising:
- (i) at least one aqueous component;
- (ii) a carrier component, the carrier component comprising:
- (1) at least one lipophilic component,
- (2) at least one surfactant, and
- (3) at least one alcohol;
- and
- (b) 5-aminolevulinic acid or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof,
- wherein the formulation comprises essentially no propylene glycol and essentially no non-cyclic polyol having 2 to 5 carbon atoms;
- irradiating the diseased or affected area of the subject's skin to which the formulation was administered with light to treat the dermatological disease.
8 more elements
A formulation comprising
- (a) a nanoemulsion, the nanoemulsion comprising:
- (i) at least one aqueous component;
- (ii) a carrier component, the carrier component comprising:
- (1) at least one lipophilic component, wherein the at least one lipophilic component is a caprylic and/or a capric triglyceride or a mixture thereof;
- (2) at least one surfactant, wherein the at least one surfactant is a phospholipid and/or a polyoxyethylene-type surfactant, and
- (3) at least one alcohol, wherein the at least one alcohol comprises 3, 4 or 5 carbon atoms;
- and
- (b) 5-aminolevulinic acid or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof,
- wherein the formulation comprises essentially no propylene glycol and essentially no sorbitol.
6 more elements
Dependencies are inferred from the claim text.