Cest lipid artifact elimination method, medium, device, and magnetic resonance imaging apparatus

A chemical exchange saturation transfer (CEST) lipid artifact elimination method based on a differential analysis with fitted magnetization transfer and lipid signals (DIGITAL), characterized in that CEST raw data acquired by a magnetic resonance imaging apparatus is read through magnetic resonance CEST imaging, lipid artifact elimination and signal extraction are performed on the acquired CEST raw data voxel-wise, and steps of processing each voxel comprise:

• Step 1:
• performing linear-interpolation-based offset correction for a main magnetic field frequency B0 on the acquired CEST raw data to obtain a corrected Z-spectrum corresponding to a target voxel;
• Step 2:
• using data comprising only MT, and data comprising a water direct saturation effect and a lipid direct saturation effect in the corrected Z-spectrum as fitting samples, fitting model parameters of a water-MT-lipid three-pool Bloch-McConnell equation model in respective given upper and lower bounds;
• and obtaining the water-MT-lipid three-pool Bloch-McConnell equation model by incorporating a lipid multi-peak model into a water-MT two-pool Bloch-McConnell equation;
• Step 3:
• inputting the fitted model parameters into the water-MT-lipid three-pool Bloch-McConnell equation model to generate a CEST reference signal of each frequency point in the corrected Z-spectrum, and subtracting an actual acquired signal in the corrected Z-spectrum from the CEST reference signal corresponding to each frequency point to obtain a CEST effect value of a CEST effect curve corresponding to a frequency point;
• Step 4:
• performing normalization on the CEST effect curve by dividing by (1−FF), wherein FF is a fat fraction obtained by fitting;
• and in the normalized CEST effect curve, a value of a frequency of interest is the CEST effect value after lipid artifact interference is eliminated.