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US 2026/0169012 A1Published application
Whole blood control sample systems and method of preparing and using the same
AssigneePerosphere Technologies Inc.
InventorsXuan Jiang, Lirong Chen, Yongchen Wang, Dardan Osmani, Stefan Zappe, Randy Byrd, Sasha H. Bakhru
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Abstract
The preparation and use of systems to provide surrogate whole blood controls using coagulation modifiers to simulate human whole blood in coagulation assays are disclosed.
Claims6
A whole blood control sample system comprising as separate components:
- a. at least one lyophilizate comprising:
- i. fixed red blood cells sourced from one or more mammalian species;
- ii. plasma sourced from one or more mammalian species;
- and
- iii. an anticoagulant selected from the group consisting of sodium citrate, acid-citrate-dextrose, and EDTA;
- b. at least one diluent;
- and
- c. at least one activation solution comprising a coagulation activator that is calcium chloride,
- wherein the at least one activation solution contains a coagulation modulator that is a serine protease inhibitor,
- wherein the at least one lyophilizate includes an effective amount of rabbit brain cephalin to further modulate clotting time of the whole blood control sample, and
- wherein the at least one diluent and the at least one lyophilizate are substantially free of the coagulation activator.
8 more elements
Dependencies are inferred from the claim text.