Compositions containing cannabinoid analog conjugates and methods of use

A method of imaging a plurality of cells in a human subject in need thereof, comprising

• (a) administering to the subject a composition comprising a conjugate of a chelator and a cannabinoid analog, wherein the chelator is chelated to a label, and wherein the conjugate is cyclam-1′-acetyl-[N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide;
• and
• (b) detecting a signal generated by the label in the subject, wherein the signal is indicative of the cells.

The method of claim 1, wherein the detecting occurs at a site of a diseased tissue or organ of the subject.

A method for treating a cancer in a human subject in need thereof, comprising administering to the human subject a composition comprising a conjugate of a chelator and a cannabinoid analog, wherein the chelator is chelated to a label, and wherein the conjugate is cyclam-1′-acetyl-[N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide.

A method for treating a neurologic disorder in a human subject in need thereof, comprising administering to the human subject in need thereof a composition comprising a conjugate of a chelator and a cannabinoid analog, wherein the chelator is chelated to a label, and wherein the conjugate is cyclam-1′-acetyl-[N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide.

A method for alleviating pain in a human subject, the method comprising:

• administering to a human subject in need thereof an effective amount a composition comprising a conjugate of a chelator and a cannabinoid analog, wherein the chelator is chelated to a label, and wherein the conjugate is cyclam-1′-acetyl-[N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide.

A kit for imaging cells, comprising:

• a predetermined quantity of a conjugate of a chelator and a cannabinoid analog, wherein the conjugate is cyclam-1′-acetyl-[N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide;
• and
• a predetermined quantity of a label, wherein the label is an imaging agent that the chelator chelates.