Methods for systems and detectors thereof including a separation media
OwnerDavid Thomas GILLESPIE, Christopher James FORMANinventors
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Abstract
Methods for a system including a detector and a separation media are disclosed. The method may include receiving input data from the detector. The input data may include an observed signal of an unknown sample and a signal of at least one known sample. The method may also include generating one or more deconvolution candidate signals based on the observed signal and using one or more deconvolution processes. The method may further include defining a domain of the detector using the one or more deconvolution processes and based on the observed signal, the calibrated separation media, the input data, or a combination thereof. The method may also include modifying the system based on the domain.
Claims28
A method for modifying a system comprising a detector and a calibrated separation media operably coupled with one another, the method comprising:
- obtaining input data from the detector, wherein the input data comprises an observed signal of an unknown sample and a signal of at least one known sample;
- generating one or more deconvolution candidate signals based on the observed signal and using one or more deconvolution processes;
- defining a domain of the detector using the one or more deconvolution processes and based on the observed signal, the calibrated separation media, the input data, or a combination thereof;
- and
- modifying the system based on the domain.
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A method for determining a dispersion corrected signal from a detector comprising a separation media, the method comprising:
- obtaining input data comprising an observed signal of an unknown sample from the detector;
- configuring the detector based on the input data to produce a calibrated separation media and a conditioned observed signal;
- generating one or more deconvolution candidate signals based on the conditioned observed signal and using one or more deconvolution processes;
- defining a domain of the dispersion corrected signal using the one or more deconvolution processes and based on the conditioned observed signal, the calibrated separation media, the input data, or a combination thereof;
- reconvolving the one or more deconvolution candidate signals based on the input data, the calibrated separation media, or a combination thereof, to produce one or more reconvolved deconvolution candidate signals;
- selecting an initial deconvolution candidate signal from the one or more deconvolution candidate signals based on the one or more reconvolved deconvolution candidate signals, the input data, or a combination thereof;
- and
- determining the dispersion corrected signal based on the initial deconvolution candidate and the domain.
Dependencies are inferred from the claim text.