Pulsation dampener for single use applications

A pulsation dampener, comprising:

• a centerbody defining a chamber including a first opening bounded by a wall defining a first surface;
• an outlet port communicating with the chamber;
• an inlet port communicating with the chamber;
• a flexible first diaphragm, wherein a perimeter of the first diaphragm is sealed to the first surface so as to define a seal that blocks the passage of fluid;
• a first cap disposed adjacent the first diaphragm, such that a first cavity is defined between the first cap and the first diaphragm;
• an inlet orifice formed in the first cap communicating with the first cavity;
• an exhaust orifice formed in the first cap communicating with the first cavity;
• and
• a valve seat disposed in the first cavity in fluid communication with the exhaust orifice, wherein the first diaphragm is moveable between an open position in which it is spaced away from the valve seat, and a closed position in which it seals against the valve seat.