Sensor stability
AssigneeGlucovation, Inc.
InventorJeffrey Suri
Life of this patent
Estimating the term…
Abstract
Sensor stability is crucial to successful, long term in situ analyte measurement. Systems, methods and devices herein exhibit increased long term measurement accuracy of circulating analytes, such as glucose, lactose, or others, which makes the technology herein particularly suitable for real time, long term in situ analyte measurement. Systems, methods and devices herein variously comprise crosslinked sensor layers, sensor sites that are internal to rather than at an edge of an insulating layer and other structural improvements, as well as sensors exhibiting the improved long-term stability in analyte measurement resulting therefrom or otherwise facilitating long term use.
Claims156
A sensor comprising
- i) a solid base;
- ii) an insulating membrane affixed to the solid base, wherein the insulating membrane comprises at least one opening that does not share a border with an exterior edge of the insulating layer, so as to expose a portion of the solid base removed from the exterior edge of the insulating layer;
- iii) a sensor layer comprising a biocompatible polymer and an analyte detection moiety capable of detecting an analyte;
- and
- iv) an exterior layer that completely envelops the sensor layer.
A method of making a sensor, the method comprising contacting a solid base to an insulating agent to form an insulating layer on the solid base;
- forming at least one hole in the insulating layer such that the solid base is exposed at the hole;
- contacting the insulating layer to a detection precursor comprising a biocompatible polymer precursor and an analyte detection moiety capable of detecting an analyte;
- polymerizing the biocompatible polymer precursor to form a sensor layer that spans at least part of the insulating layer and the at least one hole in the insulating layer;
- crosslinking at least a portion of the sensor layer to at least a portion of the insulating layer;
- contacting the sensor layer to an exterior layer agent to form an exterior layer, and crosslinking at least a portion of the sensor layer to at least a portion of the exterior layer.
A glucose sensor that exhibits a signal drift of no more than 1% of signal/hour.
A method of extending sensor performance, comprising affixing a sensor membrane to a sensor core, and binding an exterior coating to the sensor membrane, so as to prevent at least some of the sensor membrane from separating from the sensor core upon introducing a liquid to a sensor.
A method of detecting an analyte in a sample, comprising creating a voltage bias in the sample, and measuring a current passing to a conductive base through at least one opening in an insulating layer, wherein the at least one opening does not share a border with an exterior edge of the insulating layer.
Dependencies are inferred from the claim text.